许斌

    姓名：许斌

    教授、博士生导师

    办公室：E429室

    学历：博士

    职务：理学院副院长

    通信地址：上海市宝山区上大路99号

    Email：xubin@t.shu.edu.cn


    【个人简历】

    教育经历：

    1997.8 - 2000.7 理学博士，中国科学院上海有机化学研究所，金属有机化学， 导师：麻生明 院士

    1994.8 - 1997.6 理学硕士，中国科学院上海有机化学研究所，元素有机化学， 导师：朱士正 研究员

    1988.9 - 1992.7 上海科学技术大学化学系

    工作经历：

    2005.9 - 至今 化学系教授、博士生导师，上海大学理学院副院长

    2002.9 - 2005.8 Staff Scientist, 美国 VivoQuest, Inc. 药物公司

    2000.9 - 2002.8 博士后 (VFA), 美国国立卫生研究院 (National Institutes of Health, NIH),

    美国国立糖尿病、消化道及肾脏疾病研究所 (NIDDK)，药物化学，导师：Kenneth A. Jacobson


    【研究方向】

    1. 惰性化学键可控转化

    2. 药物设计与精准合成


    【人才项目】

    抗丙肝病毒含氮分子库的定向多样性合成及活性研究，上海市浦江人才计划 (No. 07pj14043) (2007.10－2009.9)


    【科研项目】

    1. 极端状态下机体能量代谢调控和组织稳态，国家重点研发计划 (No. 2023YFA1801200)(2023.12－2028.11）

    2. 异腈参与的惰性化学键可控转化，国家自然科学基金委员会 (No. 22171178)（2022.01－2025.12）

    3. 基于廉价硝酸铜的可控化学转化与含氮杂环构建，国家自然科学基金 (No. 21871174) (2019.1－2022.12)

    4. 基于廉价铜盐阴离子的精准合成及其在心肌纤维化防治中的应用，上海市教委科研创新计划“非共识”项目 (2019-01-07-00-09-E00008) (2019.1－2023.12)

    5. 异腈参与的惰性键活化与含氮杂环构建，国家自然科学基金 (No. 21672136) (2017.1－2020.12)

    6. 基于氧化胺化反应的含氮杂环合成，国家自然科学基金 (No. 21272149) (2013.1－2016.12)

    7. 基于惰性化学键活化的含氮杂环合成，上海市教委科研创新重点项目 (No.14ZZ094) (2014.01－2016.12)

    8. 金属催化的1,1-二溴-1-烯烃的多中心反应研究，国家自然科学基金 (No. 20972093) (2010.1－2012.12)

    9. 含氮杂环中的多碳-氮键形成反应研究，国家自然科学基金 (No. 20672071) (2007.1－2009.12)


    【论文著作】：第一作者或通讯作者文章 (按时间倒序排列) (2014-2024年)

    1. C–H functionalization enabled by multiple isocyanides, Mingchun Gao, Shaohang Lu and Bin Xu*, Chem. Soc. Rev. 2024, 53, 10147–10170.

    2. Synthesis of β-Carbonyl α-iminoamides by Double Insertion of Isocyanides into Aldehydes, Di Lu, Shaohang Lu, Chang-Hua Ding, Xinyao Li*, and Bin Xu*, Org. Lett. 2024, 26, 6335–6340.

    3. 1,3-Difunctionalization of Donor-Acceptor Cyclopropanes Enabled by Copper Nitrate: A Direct Approach to γ-Halonitrates, Ruoxin Huang, Mingchun Gao, Zhenkun Yang, Ziqiang Wei, Zhen Li,* Bin Xu*, Org. Lett. 2024, DOI:10.1021/acs.orglett.4c03370

    4. Brønsted Acid-Catalyzed Intramolecular Allylic Substitution Reaction of Allylic Alcohols: A Facile Synthesis of Chromans, Yun-Fan Li, Yu-Ting Xi, Kai-Ji Hu, Qitao Tan, Chang-Hua Ding*, Bin Xu*, Synlett, 2024, 35, 2148–2152.

    5. Palladium-Catalyzed Asymmetric [3+2] Cycloaddition Reaction of Vinyl Cyclopropane with Electron-Deficient Dienes, Yun-Fan Li, Cun Yang, Chang-Hua Ding* and Bin Xu*, Synlett, 2024, 35, 2101–2106.

    6. Difunctionalization of gem-Difluoroalkenes for Amination and Heteroarylation via Metal-Free Photocatalysis, Yuanchen Zhong, Zhen Zhuang, Xiaofei Zhang, Bin Xu* and Chunhao Yang*, Chem. Commun. 2024, 60, 4830–4833.

    7. Copper nitrate-enabled ring expansion reaction of cyclopropanes: A direct approach to 3-cyano-isoxazoline N-oxides, Yong Deng, Zhenkun Yang, Yanze Li, Xinyao Li,* and Bin Xu*, Org. Chem. Front., 2024, 11, 1404–1411.

    8. Oxidative isocyanide insertion of allyl compounds: A facile entry to polysubstituted 2-cyanopyrroles, Yaping Zhang, Wei Zhou, Mingchun Gao, Tianqi Liu, Bingxin Liu, Chang-Hua Ding,* and Bin Xu*, Chin. Chem. Lett. 2024, 35, 108836.

    9. Copper Nitrate-Mediated Selective Bond Cleavage of Alkynes: Diverse Synthesis of Isoxazoles, Jianan Liu, Kaijing Zhou, Shaobo Sun, Mingchun Gao,* and Bin Xu*, Chin. J. Chem. 2023, 41, 3299–3304.

    10. Direct Nitration of Vinylcycles with Copper Nitrate, Litao Zhou, Ruoxin Huang, Shaohang Lu, Bingxin Liu, Mingchun Gao*, and Bin Xu*, Org. Lett. 2023, 25, 1415–1419.

    11. Triple-consecutive isocyanide insertions with aldehydes: Synthesis of 4-cyanooxazoles, Shaohang Lu, Chang-Hua Ding,* and Bin Xu*, Org. Lett. 2023, 25, 849–854.

    12. Identification of a novel small-molecule inhibitor of miR-29b attenuates muscle atrophy, Qi Liu, Weilin Yuan, Yuwei Yan, Bing Jin, Mengke You, Tianqi Liu, Mingchun Gao, Jin Li, Priyanka Gokulnath, Gururaja Vulugundam, Guoping Li, Bin Xu*, Junjie Xiao*, Mol. Ther.-Nucl. Acids, 2023, 31, 527–540.

    13. Copper Nitrate-Mediated Regioselective Difunctionalization of Alkenes with N-Fluorobenzenesulfonimide: A Direct Approach to β-aminonitrates, Kaijing Zhou, Li Yin, Ying Guo, Chang-Hua Ding,* and Bin Xu*, Synthesis 2023, 55, 744–754.

    14. Copper-Catalyzed Sulfinyl Cross-Coupling Reaction of Sulfinamides, Mengting Kou, Ziqiang Wei, Zhen Li,* and Bin Xu*, Org. Lett. 2022, 24, 8514–8519.

    15. Multicomponent Reaction of Isocyanide, Ditelluride and Mn(III) Carboxylate: Synthesis of N-Acyl Tellurocarbamate, Jianjian Zha, Zhuoer Wang, Bingxin Liu, Qitao Tan*, Bin Xu*, Org. Lett. 2022, 24, 2863–2867.

    16. From α-Keto Acids to Nitrile Oxides Enabled by Copper Nitrate: A Facile Access to Fused Isoxazolines, Yuping Zhu, Tianqi Liu, Bingxin Liu, Houguang Shi, Qitao Tan* and Bin Xu*, Org. Chem. Front., 2022, 8, 676-681.

    17. Palladium-Catalyzed [3+2] Cycloaddition of Activated Butadienylcyclopropanes, Zhi-Xiong Yang, Yu-Qing Wei, Cun Yang, Yun-Fan Li, Chang-Hua Ding* and Bin Xu*, Asian J. Org. Chem. 2022, 11, e202100683.

    18. Synthesis of Poly-substituted Pyridines via Noble-Metal-free Formal Cycloaddition of Ketones and Imines, Yeting Mao, Hong Mao, Jiaojiao Xu, Tianqi Liu, Bingxin Liu, Qitao Tan, Chang-Hua Ding,* and Bin Xu*, Chem. Asian. J. 2021, 16, 3905-3908.

    19. PdCl2/DMSO Catalyzed Thiol–Disulfide Exchange: Synthesis of Unsymmetrical Disulfide, Jimin Guo, Jianjian Zha, Tao Zhang, Chang-Hua Ding, Qitao Tan,* Bin Xu*, Org. Lett. 2021, 23, 3167-3172.

    20. Rh(III)-Catalyzed C-H Activation/Regiospecific Annulation Cascade of Benzoic acids with Propargyl Acetates to Unusual 5-Alkylidene-Isochromanones, Jiyuan Li, Feifei Fang, Run Wang, Yuan Li, Bin Xu, Hong Liu* and Yu Zhou*, Org. Chem. Front., 2021, 8, 3876-3882.

    21. C(sp3)–H Functionalization with Isocyanides, Weixiang Wang, Tianqi Liu, Chang-Hua Ding*, and Bin Xu*, Org. Chem. Front., 2021, 8, 3525-3542.

    22. α‐Iminonitriles: Composite Functional Groups for Functionalization of Pyrene, Guigang Deng, Tianqi Liu, Yuqin Wang, Bingxin Liu, Qitao Tan,* and Bin Xu*, Asian J. Org. Chem. 2021, 10, 262-273.

    23. Cp*Rh(III)-Catalyzed C-H 3,3-Difluoroallylation of Indoles and N-Iodosuccinimide-Mediated Cyclization for the Synthesis of Fluorinated 3,4-Dihydropyrimido-[1,6-a]indol-1(2H)-one Derivatives, Sen Zhao, Chunpu Li, Bin Xu*, Hong Liu*, Chin. J. Org. Chem. 2020, 40, 1549-1562.

    24. K2S2O8-Promoted Direct Thiocyanation of Pyrazolin-5-ones with Ammonium Thiocyanate at Room Temperature, Xiaokang Mao, Jiabin Ni, Bin Xu,* Chunyong Ding*, Org. Chem. Front., 2020, 7, 350-354.

    25. Silver-Promoted Oxidative Decarboxylative C–H Alkylation of Phenanthridines with Carboxylic Acids, Tianyi Huang, Yang Yu, Hui Wang, Yifan Lin, Yurui Ma, Haoyu Wang, Chang-Hua Ding,* Junjie Xiao,* Bin Xu,*, Synthesis 2020, 52, 239-245.

    26. Silver-Assisted Oxidative Isocyanide Insertion of Ethers: A Direct Approach to β-Carbonyl α-Iminonitriles, Leiyang Zhao, Bingxin Liu, Qitao Tan, Chang-Hua Ding*, Bin Xu*, Org. Lett. 2019, 21, 9223-9227.

    27. From Isocyanides to Iminonitriles via Silver-Catalyzed Sequential Insertion of C(sp3)–H Bond, Huiwen Chi, Hao Li, Bingxin Liu, Rongxuan Ye, Haoyang Wang, Yin-Long Guo, Qitao Tan* and Bin Xu*, iScience 2019, 21, 650-663.

    28. Synthesis of Tellurium-Containing π-Extended Aromatics with Room-Temperature Phosphorescence, Mengjing Jiang, Jimin Guo, Bingxin Liu, Qitao Tan,* and Bin Xu*, Org. Lett. 2019, 21, 8328-8333.

    29. From Alkenes to Isoxazolines via Copper-Mediated Alkene Cleavage and Dipolar Cycloaddition, Mingchun Gao, Yuansheng Gan, and Bin Xu*, Org. Lett. 2019, 21, 7435-7439.

    30. An Isoxazole Derivative SHU00238 Suppresses Colorectal Cancer Growth through miRNAs Regulation, Haoyu Wang, Yurui Ma, Yifan Lin, Jiajie Liu, Rui Chen, Bin Xu,* Yajun Liang*, Molecules 2019, 24, 2335.

    31. Copper nitrate-mediated synthesis of 3-aryl isoxazolines and isoxazoles from olefinic azlactones, Yifan Lin, Ke Zhang, Mingchun Gao, Zheyi Jiang, Jiajie Liu, Yurui Ma, Haoyu Wang, Qitao Tan*, Junjie Xiao* and Bin Xu*, Org. Biomol. Chem., 2019, 17, 5509–5513.

    32. Copper Nitrate-Mediated Selective Difunctionalization of Alkenes: A Rapid Access to β-Bromonitrates, Mingchun Gao, Kaijing Zhou, and Bin Xu*, Adv. Synth. Catal. 2019, 361, 2031–2036.

    33. Palladium-Catalyzed Multicomponent Reaction of Alkynes, Carboxylic Acids, and Isocyanides: A Direct Approach to Captodative Olefins, Mingchun Gao, Minfen Zou, Jue Wang, Qitao Tan, Bingxin Liu, and Bin Xu*, Org. Lett. 2019, 21, 1593–1597.

    34. Ligand-free nickel-catalyzed Kumada couplings of aryl bromides with tert-butyl Grignard reagents, Zhenghan Wu, Tengda Si, Guangqing Xu, Bin Xu*, Wenjun Tang,*, Chin. Chem. Lett. 2019, 30, 597-600.

    35. Cyclization of 2-biphenylthiols to dibenzothiophenes under PdCl2/DMSO catalysis, Tao Zhang, Guigang Deng, Hanjie Li, Bingxin Liu, Qitao Tan,* and Bin Xu,*, Org. Lett. 2018, 20, 5439-5443.

    36. Access to Spiroindolines and Spirodihydrobenzofurans via Pd-Catalyzed Domino Heck Spiroyclization through C-H Activation and Carbene Insertion, Jian-Guo Liu, Wen-Wen Chen,* Chang-Xue Gu, Bin Xu,* Ming-Hua Xu*, Org. Lett., 2018, 20, 2728-2732.

    37. Copper-Catalyzed Synthesis of Polysubstituted Pyrroles through [3+1+1] Cycloaddition Reaction of Nitrones and Isocyanides, Zhuang Tian, Jiaojiao Xu, Bingxin Liu, Qitao Tan,* Bin Xu*, Org. Lett., 2018, 20, 2603-2606.

    38. Copper nitrate: A privileged reagent for organic synthesis, Mingchun Gao, Rongxuan Ye, Weijia Shen and Bin Xu*, Org. Biomol. Chem., 2018, 16, 2602-2618.

    39. Efficient cross-coupling of aryl/alkenyl triflates with acyclic secondary alkylboronic acids, Tengda Si, Bowen Li, Wenrui Xiong, Bin Xu,* and Wenjun Tang*, Org. Biomol. Chem., 2017, 15, 9903-9909.

    40. Copper-Catalyzed Aerobic Annulation of Hydrazones: Direct Access to Cinnolines, Chunling Lan, Zhuang Tian, Xuchun Liang, Mingchun Gao, Wenting Liu, Yu An, Wencheng Fu, Guanming Jiao, Junjie Xiao, and Bin Xu*, Adv. Synth. Catal. 2017, 359, 3735-3740.

    41. Iodine-doped Sumanene and Its Application for the Synthesis of Chalcogenasumanenes and Silasumanenes, Qitao Tan*, Dandan Zhou, Tao Zhang, Bingxin Liu, Bin Xu*, Chem. Commun. 2017, 53, 10279-10282.

    42. Synthesis of Silicon and Germanium-Containing Heterosumanenes via Rhodium-Catalyzed Cyclodehydrogenation of Silicon/Germanium-Hydrogen and Carbon-Hydrogen Bonds, Dandan Zhou, Ya Gao, Bingxin Liu, Qitao Tan*, Bin Xu*, Org. Lett., 2017, 19, 4628-4631.

    43. Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)-ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis, Zong-Feng Zhang, Dong-Xing Zhu, Wen-Wen Chen, Bin Xu*, Ming-Hua Xu*, Org. Lett. 2017, 19, 2726-2729.

    44. Isocyanide Induced Activation of Copper Sulfate: Direct Access to Functionalized Heteroarene Sulfonic Esters, Xiaohu Hong, Qitao Tan, Bingxin Liu, Bin Xu*, Angew. Chem., Int. Ed. 2017, 56, 3961-3965.

    45. Development of a new analog of SGK1 inhibitor and its evaluation as a therapeutic molecule of colorectal cancer, Xuchun Liang#, Chunling Lan#, Jinzhe Zhou#, Wencheng Fu, Xuesha Long, Yu An, Guanming Jiao, Kejin Wang, Yongqin Li, Jiahong Xu, Qi Huang, Bin Xu*, Junjie Xiao*, J. Cancer 2017, 8, 2256-2262.

    46. Therapeutic inhibition of SGK1 suppresses colorectal cancer, Xuchun Liang#, Chunling Lan#, Guanming Jiao#, Wencheng Fu, Xuesha Long, Yu An, Kejin Wang, Jinzhe Zhou, Ting Chen, Yongqin Li, Jiahong Xu, Qi Huang, Bin Xu*, Junjie Xiao* Experimental & Molecular Medicine 2017, 49, e399.

    47. Copper Nitrate-Mediated Chemo- and Regioselective Annulation from Two Different Alkynes: A Direct Route to Isoxazoles., Yingying Li, Mingchun Gao, Bingxin Liu, Bin Xu*, Org. Chem. Front., 2017, 4, 445-449.

    48. Metal-catalyzed C–H Functionalization Involving Isocyanides, Bingrui Song, Bin Xu*, Chem. Soc. Rev. 2017, 46, 1103-1123. (Cover Picture)

    49. Copper Nitrate-Mediated Regio- and Stereoselective Difunctionalization of Alkynes: A Direct Approach to α-Chloro-β-nitroolefins., Mingchun Gao, Bin Xu*, Org. Lett. 2016, 18, 4746-4749.

    50. Rhodium-catalyzed asymmetric arylation of N- and O-containing cyclic aldimines: facile and efficient access to highly optically active 3,4-dihydrobenzo[1,4]oxazin-2-ones and dihydroquinoxalinones, Xu Zhang, Bin Xu*, Ming-Hua Xu*, Org. Chem. Front., 2016, 3, 944-948.

    51. Transition Metal-Participated Synthesis and Utilization of N-containing Heterocycles: Exploring for Nitrogen Sources, Mingchun Gao, Bin Xu*,, Chem. Rec., 2016, 16, 1701-1714.

    52. C−H Bond Activation as a Powerful Tool in the Construction of Biologically Active Nitrogen Containing Heterocycles, Qitao Tan, Bin Xu*,, Studies in Natural Products Chemistry, 2016, 50, 299-340. (Invited book chapter).

    53. Manganese(II)-catalyzed modular synthesis of isoquinolines from vinyl isocyanides and hydrazines, Hong Mao, Mingchun Gao, Bingxin Liu and Bin Xu,*, Org. Chem. Front. 2016, 3, 516-521.

    54. Intramolecular cross dehydrogenative coupling of 4-substituted coumarins: rapid and efficient access to coumestans and indole[3,2-c]coumarins., Chao Cheng, Wen-Wen Chen*, Bin Xu, Ming-Hua Xu*, Org. Chem. Front., 2016, 3, 1111-1115.

    55. Parent and Trisubstituted Triazacoronenes: Synthesis, Crystal Structure and Physicochemical Properties Qitao Tan,* Huanhuan Chen, Huaida Xia, Bingxin Liu, Bin Xu*, 56. Chem. Commun. 2016, 52, 537-540.

    57. Study on the Degradation of the Highly Reactive Hypervalent Trifluoromethylation Iodine Reagent PhI(OAc)(CF3), Hui Zhu, Shusheng Zhang, Haoyang Wang, Bin Xu,* and Yinlong Guo*,, Chin. J. Chem. 2015, 33, 1365-1370.

    58. Kinetic Resolution of 2-Substituted-2,3-dihydrofurans by Palladium-Catalyzed Asymmetric Heck Reaction, Hao Li, Shi-Li Wan, Chang-Hua Ding,* Bin Xu*, Xue-Long Hou, RSC Advances 2015, 5, 75411-75414.

    59. Copper Nitrate-Mediated Regioselective [2+2+1] Cyclization of Alkynes with Alkenes: A Cascade Approach to Δ2-Isoxazolines, Mingchun Gao, Yingying Li, Yuansheng Gan, Bin Xu*,, Angew. Chem., Int. Ed. 2015, 54, 8795-8799. (Cover Picture)

    60. Copper-Promoted Oxidative C−H Bond Amination of Hydrazones: Synthesis of 1H-Indazoles and 1H-Pyrazoles, Zhengwei Ding, Qitao Tan*, Bingxin Liu, Ke Zhang, Bin Xu*,, Acta Chim. Sinica 2015, 73, 1302-1306.

    61. Copper-catalyzed Aerobic Cascade Cycloamination and Acyloxylation: A Direct Approach to 4-Acyloxy-1H-pyrazoles, Zhengwei Ding, Qitao Tan, Mingchun Gao, Bin Xu*,, Org. Biomol. Chem. 2015, 13, 4642-4646.

    62. Recent Advances in Inert Bonds Activation with Isocyanides, Hao Wang, Bin Xu*,, Chin. J. Org. Chem. 2015, 35, 588-602. (Invited Review)

    63. Rhodim-Catalyzed Regioselective C−H Chlorination of 7-Azaindoles Using 1,2-Dichloroethane, Guangyin Qian, Xiaohu Hong, Bingxin Liu*, Hong Mao, Bin Xu*,, Org. Lett. 2014, 16, 5294-5297.

    64. Ruthenium-Catalyzed Double-Fold C–H Tertiary Alkoxycarbonylation of Arenes Using Di-tert-butyl Dicarbonate, Xiaohu Hong, Hao Wang, Bingxin Liu, Bin Xu*,, Chem. Commun. 2014, 50, 14129-14132.

    65. Mn(II)/O2-Promoted Oxidative Annulation of Vinyl Isocyanides with Boronic Acids: Synthesis of Multi-substituted Isoquinolines, Hao Wang, Yang Yu, Xiaohu Hong, Bin Xu*,, Chem. Commun. 2014, 50, 13485-13488.

    66. Hypervalent Iodine(III)-Promoted Direct Synthesis of Imidazo[1,2-a]pyrimidines Guangyin Qian, Bingxin Liu, Qitao Tan, Siwen Zhang, Bin Xu*,, 67. Eur. J. Org. Chem. 2014, 2014, 4837-4843.

    68. Palladium-Catalyzed Oxidative Annulation of Hydrazides with Isocyanides: Synthesis of 2-Amino-1,3,4-oxadiazoles, Tao Fang, Qitao Tan, Zhengwei Ding, Bingxin Liu, Bin Xu*,, Org. Lett. 2014, 16, 2342-2345.

    69. Rhodium-Catalyzed Direct ortho C–N Bond Formation of Aromatic Azo Compounds with Azides, Hao Wang, Yang Yu, Xiaohu Hong, Qitao Tan, Bin Xu*,, J. Org. Chem. 2014, 79, 3279-3288.

    70. Rhodium-Catalyzed Direct C–H Bond Cyanation of Arenes with Isocyanide, Xiaohu Hong, Hao Wang, Guangyin Qian, Qitao Tan, Bin Xu*,, J. Org. Chem. 2014, 79, 3228-3237.

    71. Copper-mediated Tandem Reaction through Isocyanides N–H Bond Insertion: Efficient Access to Unsymmetrical Tetrasubstituted Ureas, Xiaomei Huang, Shuguang Xu, Qitao Tan, Mingchun Gao, Minjie Li, Bin Xu*,, Chem. Commun. 2014, 50, 1465-1468.

    72. Copper-Catalyzed Aerobic Oxidative Annulation and Carbon-Carbon Bond Cleavage of Arylacetamides: Domino Synthesis of Fused Quinazolinones, Jie Sun, Qitao Tan, Wusong Yang, Bingxin Liu, Bin Xu*,, Adv. Synth. Catal. 2014, 356, 388-394.


    （最后更新日期：2024.10.31）

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    许斌

      姓名：许斌

      教授、博士生导师

      办公室：E429室

      学历：博士

      职务：理学院副院长

      通信地址：上海市宝山区上大路99号

      Email：xubin@t.shu.edu.cn


      【个人简历】

      教育经历：

      1997.8 - 2000.7 理学博士，中国科学院上海有机化学研究所，金属有机化学， 导师：麻生明 院士

      1994.8 - 1997.6 理学硕士，中国科学院上海有机化学研究所，元素有机化学， 导师：朱士正 研究员

      1988.9 - 1992.7 上海科学技术大学化学系

      工作经历：

      2005.9 - 至今 化学系教授、博士生导师，上海大学理学院副院长

      2002.9 - 2005.8 Staff Scientist, 美国 VivoQuest, Inc. 药物公司

      2000.9 - 2002.8 博士后 (VFA), 美国国立卫生研究院 (National Institutes of Health, NIH),

      美国国立糖尿病、消化道及肾脏疾病研究所 (NIDDK)，药物化学，导师：Kenneth A. Jacobson


      【研究方向】

      1. 惰性化学键可控转化

      2. 药物设计与精准合成


      【人才项目】

      抗丙肝病毒含氮分子库的定向多样性合成及活性研究，上海市浦江人才计划 (No. 07pj14043) (2007.10－2009.9)


      【科研项目】

      1. 极端状态下机体能量代谢调控和组织稳态，国家重点研发计划 (No. 2023YFA1801200)(2023.12－2028.11）

      2. 异腈参与的惰性化学键可控转化，国家自然科学基金委员会 (No. 22171178)（2022.01－2025.12）

      3. 基于廉价硝酸铜的可控化学转化与含氮杂环构建，国家自然科学基金 (No. 21871174) (2019.1－2022.12)

      4. 基于廉价铜盐阴离子的精准合成及其在心肌纤维化防治中的应用，上海市教委科研创新计划“非共识”项目 (2019-01-07-00-09-E00008) (2019.1－2023.12)

      5. 异腈参与的惰性键活化与含氮杂环构建，国家自然科学基金 (No. 21672136) (2017.1－2020.12)

      6. 基于氧化胺化反应的含氮杂环合成，国家自然科学基金 (No. 21272149) (2013.1－2016.12)

      7. 基于惰性化学键活化的含氮杂环合成，上海市教委科研创新重点项目 (No.14ZZ094) (2014.01－2016.12)

      8. 金属催化的1,1-二溴-1-烯烃的多中心反应研究，国家自然科学基金 (No. 20972093) (2010.1－2012.12)

      9. 含氮杂环中的多碳-氮键形成反应研究，国家自然科学基金 (No. 20672071) (2007.1－2009.12)


      【论文著作】：第一作者或通讯作者文章 (按时间倒序排列) (2014-2024年)

      1. C–H functionalization enabled by multiple isocyanides, Mingchun Gao, Shaohang Lu and Bin Xu*, Chem. Soc. Rev. 2024, 53, 10147–10170.

      2. Synthesis of β-Carbonyl α-iminoamides by Double Insertion of Isocyanides into Aldehydes, Di Lu, Shaohang Lu, Chang-Hua Ding, Xinyao Li*, and Bin Xu*, Org. Lett. 2024, 26, 6335–6340.

      3. 1,3-Difunctionalization of Donor-Acceptor Cyclopropanes Enabled by Copper Nitrate: A Direct Approach to γ-Halonitrates, Ruoxin Huang, Mingchun Gao, Zhenkun Yang, Ziqiang Wei, Zhen Li,* Bin Xu*, Org. Lett. 2024, DOI:10.1021/acs.orglett.4c03370

      4. Brønsted Acid-Catalyzed Intramolecular Allylic Substitution Reaction of Allylic Alcohols: A Facile Synthesis of Chromans, Yun-Fan Li, Yu-Ting Xi, Kai-Ji Hu, Qitao Tan, Chang-Hua Ding*, Bin Xu*, Synlett, 2024, 35, 2148–2152.

      5. Palladium-Catalyzed Asymmetric [3+2] Cycloaddition Reaction of Vinyl Cyclopropane with Electron-Deficient Dienes, Yun-Fan Li, Cun Yang, Chang-Hua Ding* and Bin Xu*, Synlett, 2024, 35, 2101–2106.

      6. Difunctionalization of gem-Difluoroalkenes for Amination and Heteroarylation via Metal-Free Photocatalysis, Yuanchen Zhong, Zhen Zhuang, Xiaofei Zhang, Bin Xu* and Chunhao Yang*, Chem. Commun. 2024, 60, 4830–4833.

      7. Copper nitrate-enabled ring expansion reaction of cyclopropanes: A direct approach to 3-cyano-isoxazoline N-oxides, Yong Deng, Zhenkun Yang, Yanze Li, Xinyao Li,* and Bin Xu*, Org. Chem. Front., 2024, 11, 1404–1411.

      8. Oxidative isocyanide insertion of allyl compounds: A facile entry to polysubstituted 2-cyanopyrroles, Yaping Zhang, Wei Zhou, Mingchun Gao, Tianqi Liu, Bingxin Liu, Chang-Hua Ding,* and Bin Xu*, Chin. Chem. Lett. 2024, 35, 108836.

      9. Copper Nitrate-Mediated Selective Bond Cleavage of Alkynes: Diverse Synthesis of Isoxazoles, Jianan Liu, Kaijing Zhou, Shaobo Sun, Mingchun Gao,* and Bin Xu*, Chin. J. Chem. 2023, 41, 3299–3304.

      10. Direct Nitration of Vinylcycles with Copper Nitrate, Litao Zhou, Ruoxin Huang, Shaohang Lu, Bingxin Liu, Mingchun Gao*, and Bin Xu*, Org. Lett. 2023, 25, 1415–1419.

      11. Triple-consecutive isocyanide insertions with aldehydes: Synthesis of 4-cyanooxazoles, Shaohang Lu, Chang-Hua Ding,* and Bin Xu*, Org. Lett. 2023, 25, 849–854.

      12. Identification of a novel small-molecule inhibitor of miR-29b attenuates muscle atrophy, Qi Liu, Weilin Yuan, Yuwei Yan, Bing Jin, Mengke You, Tianqi Liu, Mingchun Gao, Jin Li, Priyanka Gokulnath, Gururaja Vulugundam, Guoping Li, Bin Xu*, Junjie Xiao*, Mol. Ther.-Nucl. Acids, 2023, 31, 527–540.

      13. Copper Nitrate-Mediated Regioselective Difunctionalization of Alkenes with N-Fluorobenzenesulfonimide: A Direct Approach to β-aminonitrates, Kaijing Zhou, Li Yin, Ying Guo, Chang-Hua Ding,* and Bin Xu*, Synthesis 2023, 55, 744–754.

      14. Copper-Catalyzed Sulfinyl Cross-Coupling Reaction of Sulfinamides, Mengting Kou, Ziqiang Wei, Zhen Li,* and Bin Xu*, Org. Lett. 2022, 24, 8514–8519.

      15. Multicomponent Reaction of Isocyanide, Ditelluride and Mn(III) Carboxylate: Synthesis of N-Acyl Tellurocarbamate, Jianjian Zha, Zhuoer Wang, Bingxin Liu, Qitao Tan*, Bin Xu*, Org. Lett. 2022, 24, 2863–2867.

      16. From α-Keto Acids to Nitrile Oxides Enabled by Copper Nitrate: A Facile Access to Fused Isoxazolines, Yuping Zhu, Tianqi Liu, Bingxin Liu, Houguang Shi, Qitao Tan* and Bin Xu*, Org. Chem. Front., 2022, 8, 676-681.

      17. Palladium-Catalyzed [3+2] Cycloaddition of Activated Butadienylcyclopropanes, Zhi-Xiong Yang, Yu-Qing Wei, Cun Yang, Yun-Fan Li, Chang-Hua Ding* and Bin Xu*, Asian J. Org. Chem. 2022, 11, e202100683.

      18. Synthesis of Poly-substituted Pyridines via Noble-Metal-free Formal Cycloaddition of Ketones and Imines, Yeting Mao, Hong Mao, Jiaojiao Xu, Tianqi Liu, Bingxin Liu, Qitao Tan, Chang-Hua Ding,* and Bin Xu*, Chem. Asian. J. 2021, 16, 3905-3908.

      19. PdCl2/DMSO Catalyzed Thiol–Disulfide Exchange: Synthesis of Unsymmetrical Disulfide, Jimin Guo, Jianjian Zha, Tao Zhang, Chang-Hua Ding, Qitao Tan,* Bin Xu*, Org. Lett. 2021, 23, 3167-3172.

      20. Rh(III)-Catalyzed C-H Activation/Regiospecific Annulation Cascade of Benzoic acids with Propargyl Acetates to Unusual 5-Alkylidene-Isochromanones, Jiyuan Li, Feifei Fang, Run Wang, Yuan Li, Bin Xu, Hong Liu* and Yu Zhou*, Org. Chem. Front., 2021, 8, 3876-3882.

      21. C(sp3)–H Functionalization with Isocyanides, Weixiang Wang, Tianqi Liu, Chang-Hua Ding*, and Bin Xu*, Org. Chem. Front., 2021, 8, 3525-3542.

      22. α‐Iminonitriles: Composite Functional Groups for Functionalization of Pyrene, Guigang Deng, Tianqi Liu, Yuqin Wang, Bingxin Liu, Qitao Tan,* and Bin Xu*, Asian J. Org. Chem. 2021, 10, 262-273.

      23. Cp*Rh(III)-Catalyzed C-H 3,3-Difluoroallylation of Indoles and N-Iodosuccinimide-Mediated Cyclization for the Synthesis of Fluorinated 3,4-Dihydropyrimido-[1,6-a]indol-1(2H)-one Derivatives, Sen Zhao, Chunpu Li, Bin Xu*, Hong Liu*, Chin. J. Org. Chem. 2020, 40, 1549-1562.

      24. K2S2O8-Promoted Direct Thiocyanation of Pyrazolin-5-ones with Ammonium Thiocyanate at Room Temperature, Xiaokang Mao, Jiabin Ni, Bin Xu,* Chunyong Ding*, Org. Chem. Front., 2020, 7, 350-354.

      25. Silver-Promoted Oxidative Decarboxylative C–H Alkylation of Phenanthridines with Carboxylic Acids, Tianyi Huang, Yang Yu, Hui Wang, Yifan Lin, Yurui Ma, Haoyu Wang, Chang-Hua Ding,* Junjie Xiao,* Bin Xu,*, Synthesis 2020, 52, 239-245.

      26. Silver-Assisted Oxidative Isocyanide Insertion of Ethers: A Direct Approach to β-Carbonyl α-Iminonitriles, Leiyang Zhao, Bingxin Liu, Qitao Tan, Chang-Hua Ding*, Bin Xu*, Org. Lett. 2019, 21, 9223-9227.

      27. From Isocyanides to Iminonitriles via Silver-Catalyzed Sequential Insertion of C(sp3)–H Bond, Huiwen Chi, Hao Li, Bingxin Liu, Rongxuan Ye, Haoyang Wang, Yin-Long Guo, Qitao Tan* and Bin Xu*, iScience 2019, 21, 650-663.

      28. Synthesis of Tellurium-Containing π-Extended Aromatics with Room-Temperature Phosphorescence, Mengjing Jiang, Jimin Guo, Bingxin Liu, Qitao Tan,* and Bin Xu*, Org. Lett. 2019, 21, 8328-8333.

      29. From Alkenes to Isoxazolines via Copper-Mediated Alkene Cleavage and Dipolar Cycloaddition, Mingchun Gao, Yuansheng Gan, and Bin Xu*, Org. Lett. 2019, 21, 7435-7439.

      30. An Isoxazole Derivative SHU00238 Suppresses Colorectal Cancer Growth through miRNAs Regulation, Haoyu Wang, Yurui Ma, Yifan Lin, Jiajie Liu, Rui Chen, Bin Xu,* Yajun Liang*, Molecules 2019, 24, 2335.

      31. Copper nitrate-mediated synthesis of 3-aryl isoxazolines and isoxazoles from olefinic azlactones, Yifan Lin, Ke Zhang, Mingchun Gao, Zheyi Jiang, Jiajie Liu, Yurui Ma, Haoyu Wang, Qitao Tan*, Junjie Xiao* and Bin Xu*, Org. Biomol. Chem., 2019, 17, 5509–5513.

      32. Copper Nitrate-Mediated Selective Difunctionalization of Alkenes: A Rapid Access to β-Bromonitrates, Mingchun Gao, Kaijing Zhou, and Bin Xu*, Adv. Synth. Catal. 2019, 361, 2031–2036.

      33. Palladium-Catalyzed Multicomponent Reaction of Alkynes, Carboxylic Acids, and Isocyanides: A Direct Approach to Captodative Olefins, Mingchun Gao, Minfen Zou, Jue Wang, Qitao Tan, Bingxin Liu, and Bin Xu*, Org. Lett. 2019, 21, 1593–1597.

      34. Ligand-free nickel-catalyzed Kumada couplings of aryl bromides with tert-butyl Grignard reagents, Zhenghan Wu, Tengda Si, Guangqing Xu, Bin Xu*, Wenjun Tang,*, Chin. Chem. Lett. 2019, 30, 597-600.

      35. Cyclization of 2-biphenylthiols to dibenzothiophenes under PdCl2/DMSO catalysis, Tao Zhang, Guigang Deng, Hanjie Li, Bingxin Liu, Qitao Tan,* and Bin Xu,*, Org. Lett. 2018, 20, 5439-5443.

      36. Access to Spiroindolines and Spirodihydrobenzofurans via Pd-Catalyzed Domino Heck Spiroyclization through C-H Activation and Carbene Insertion, Jian-Guo Liu, Wen-Wen Chen,* Chang-Xue Gu, Bin Xu,* Ming-Hua Xu*, Org. Lett., 2018, 20, 2728-2732.

      37. Copper-Catalyzed Synthesis of Polysubstituted Pyrroles through [3+1+1] Cycloaddition Reaction of Nitrones and Isocyanides, Zhuang Tian, Jiaojiao Xu, Bingxin Liu, Qitao Tan,* Bin Xu*, Org. Lett., 2018, 20, 2603-2606.

      38. Copper nitrate: A privileged reagent for organic synthesis, Mingchun Gao, Rongxuan Ye, Weijia Shen and Bin Xu*, Org. Biomol. Chem., 2018, 16, 2602-2618.

      39. Efficient cross-coupling of aryl/alkenyl triflates with acyclic secondary alkylboronic acids, Tengda Si, Bowen Li, Wenrui Xiong, Bin Xu,* and Wenjun Tang*, Org. Biomol. Chem., 2017, 15, 9903-9909.

      40. Copper-Catalyzed Aerobic Annulation of Hydrazones: Direct Access to Cinnolines, Chunling Lan, Zhuang Tian, Xuchun Liang, Mingchun Gao, Wenting Liu, Yu An, Wencheng Fu, Guanming Jiao, Junjie Xiao, and Bin Xu*, Adv. Synth. Catal. 2017, 359, 3735-3740.

      41. Iodine-doped Sumanene and Its Application for the Synthesis of Chalcogenasumanenes and Silasumanenes, Qitao Tan*, Dandan Zhou, Tao Zhang, Bingxin Liu, Bin Xu*, Chem. Commun. 2017, 53, 10279-10282.

      42. Synthesis of Silicon and Germanium-Containing Heterosumanenes via Rhodium-Catalyzed Cyclodehydrogenation of Silicon/Germanium-Hydrogen and Carbon-Hydrogen Bonds, Dandan Zhou, Ya Gao, Bingxin Liu, Qitao Tan*, Bin Xu*, Org. Lett., 2017, 19, 4628-4631.

      43. Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)-ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis, Zong-Feng Zhang, Dong-Xing Zhu, Wen-Wen Chen, Bin Xu*, Ming-Hua Xu*, Org. Lett. 2017, 19, 2726-2729.

      44. Isocyanide Induced Activation of Copper Sulfate: Direct Access to Functionalized Heteroarene Sulfonic Esters, Xiaohu Hong, Qitao Tan, Bingxin Liu, Bin Xu*, Angew. Chem., Int. Ed. 2017, 56, 3961-3965.

      45. Development of a new analog of SGK1 inhibitor and its evaluation as a therapeutic molecule of colorectal cancer, Xuchun Liang#, Chunling Lan#, Jinzhe Zhou#, Wencheng Fu, Xuesha Long, Yu An, Guanming Jiao, Kejin Wang, Yongqin Li, Jiahong Xu, Qi Huang, Bin Xu*, Junjie Xiao*, J. Cancer 2017, 8, 2256-2262.

      46. Therapeutic inhibition of SGK1 suppresses colorectal cancer, Xuchun Liang#, Chunling Lan#, Guanming Jiao#, Wencheng Fu, Xuesha Long, Yu An, Kejin Wang, Jinzhe Zhou, Ting Chen, Yongqin Li, Jiahong Xu, Qi Huang, Bin Xu*, Junjie Xiao* Experimental & Molecular Medicine 2017, 49, e399.

      47. Copper Nitrate-Mediated Chemo- and Regioselective Annulation from Two Different Alkynes: A Direct Route to Isoxazoles., Yingying Li, Mingchun Gao, Bingxin Liu, Bin Xu*, Org. Chem. Front., 2017, 4, 445-449.

      48. Metal-catalyzed C–H Functionalization Involving Isocyanides, Bingrui Song, Bin Xu*, Chem. Soc. Rev. 2017, 46, 1103-1123. (Cover Picture)

      49. Copper Nitrate-Mediated Regio- and Stereoselective Difunctionalization of Alkynes: A Direct Approach to α-Chloro-β-nitroolefins., Mingchun Gao, Bin Xu*, Org. Lett. 2016, 18, 4746-4749.

      50. Rhodium-catalyzed asymmetric arylation of N- and O-containing cyclic aldimines: facile and efficient access to highly optically active 3,4-dihydrobenzo[1,4]oxazin-2-ones and dihydroquinoxalinones, Xu Zhang, Bin Xu*, Ming-Hua Xu*, Org. Chem. Front., 2016, 3, 944-948.

      51. Transition Metal-Participated Synthesis and Utilization of N-containing Heterocycles: Exploring for Nitrogen Sources, Mingchun Gao, Bin Xu*,, Chem. Rec., 2016, 16, 1701-1714.

      52. C−H Bond Activation as a Powerful Tool in the Construction of Biologically Active Nitrogen Containing Heterocycles, Qitao Tan, Bin Xu*,, Studies in Natural Products Chemistry, 2016, 50, 299-340. (Invited book chapter).

      53. Manganese(II)-catalyzed modular synthesis of isoquinolines from vinyl isocyanides and hydrazines, Hong Mao, Mingchun Gao, Bingxin Liu and Bin Xu,*, Org. Chem. Front. 2016, 3, 516-521.

      54. Intramolecular cross dehydrogenative coupling of 4-substituted coumarins: rapid and efficient access to coumestans and indole[3,2-c]coumarins., Chao Cheng, Wen-Wen Chen*, Bin Xu, Ming-Hua Xu*, Org. Chem. Front., 2016, 3, 1111-1115.

      55. Parent and Trisubstituted Triazacoronenes: Synthesis, Crystal Structure and Physicochemical Properties Qitao Tan,* Huanhuan Chen, Huaida Xia, Bingxin Liu, Bin Xu*, 56. Chem. Commun. 2016, 52, 537-540.

      57. Study on the Degradation of the Highly Reactive Hypervalent Trifluoromethylation Iodine Reagent PhI(OAc)(CF3), Hui Zhu, Shusheng Zhang, Haoyang Wang, Bin Xu,* and Yinlong Guo*,, Chin. J. Chem. 2015, 33, 1365-1370.

      58. Kinetic Resolution of 2-Substituted-2,3-dihydrofurans by Palladium-Catalyzed Asymmetric Heck Reaction, Hao Li, Shi-Li Wan, Chang-Hua Ding,* Bin Xu*, Xue-Long Hou, RSC Advances 2015, 5, 75411-75414.

      59. Copper Nitrate-Mediated Regioselective [2+2+1] Cyclization of Alkynes with Alkenes: A Cascade Approach to Δ2-Isoxazolines, Mingchun Gao, Yingying Li, Yuansheng Gan, Bin Xu*,, Angew. Chem., Int. Ed. 2015, 54, 8795-8799. (Cover Picture)

      60. Copper-Promoted Oxidative C−H Bond Amination of Hydrazones: Synthesis of 1H-Indazoles and 1H-Pyrazoles, Zhengwei Ding, Qitao Tan*, Bingxin Liu, Ke Zhang, Bin Xu*,, Acta Chim. Sinica 2015, 73, 1302-1306.

      61. Copper-catalyzed Aerobic Cascade Cycloamination and Acyloxylation: A Direct Approach to 4-Acyloxy-1H-pyrazoles, Zhengwei Ding, Qitao Tan, Mingchun Gao, Bin Xu*,, Org. Biomol. Chem. 2015, 13, 4642-4646.

      62. Recent Advances in Inert Bonds Activation with Isocyanides, Hao Wang, Bin Xu*,, Chin. J. Org. Chem. 2015, 35, 588-602. (Invited Review)

      63. Rhodim-Catalyzed Regioselective C−H Chlorination of 7-Azaindoles Using 1,2-Dichloroethane, Guangyin Qian, Xiaohu Hong, Bingxin Liu*, Hong Mao, Bin Xu*,, Org. Lett. 2014, 16, 5294-5297.

      64. Ruthenium-Catalyzed Double-Fold C–H Tertiary Alkoxycarbonylation of Arenes Using Di-tert-butyl Dicarbonate, Xiaohu Hong, Hao Wang, Bingxin Liu, Bin Xu*,, Chem. Commun. 2014, 50, 14129-14132.

      65. Mn(II)/O2-Promoted Oxidative Annulation of Vinyl Isocyanides with Boronic Acids: Synthesis of Multi-substituted Isoquinolines, Hao Wang, Yang Yu, Xiaohu Hong, Bin Xu*,, Chem. Commun. 2014, 50, 13485-13488.

      66. Hypervalent Iodine(III)-Promoted Direct Synthesis of Imidazo[1,2-a]pyrimidines Guangyin Qian, Bingxin Liu, Qitao Tan, Siwen Zhang, Bin Xu*,, 67. Eur. J. Org. Chem. 2014, 2014, 4837-4843.

      68. Palladium-Catalyzed Oxidative Annulation of Hydrazides with Isocyanides: Synthesis of 2-Amino-1,3,4-oxadiazoles, Tao Fang, Qitao Tan, Zhengwei Ding, Bingxin Liu, Bin Xu*,, Org. Lett. 2014, 16, 2342-2345.

      69. Rhodium-Catalyzed Direct ortho C–N Bond Formation of Aromatic Azo Compounds with Azides, Hao Wang, Yang Yu, Xiaohu Hong, Qitao Tan, Bin Xu*,, J. Org. Chem. 2014, 79, 3279-3288.

      70. Rhodium-Catalyzed Direct C–H Bond Cyanation of Arenes with Isocyanide, Xiaohu Hong, Hao Wang, Guangyin Qian, Qitao Tan, Bin Xu*,, J. Org. Chem. 2014, 79, 3228-3237.

      71. Copper-mediated Tandem Reaction through Isocyanides N–H Bond Insertion: Efficient Access to Unsymmetrical Tetrasubstituted Ureas, Xiaomei Huang, Shuguang Xu, Qitao Tan, Mingchun Gao, Minjie Li, Bin Xu*,, Chem. Commun. 2014, 50, 1465-1468.

      72. Copper-Catalyzed Aerobic Oxidative Annulation and Carbon-Carbon Bond Cleavage of Arylacetamides: Domino Synthesis of Fused Quinazolinones, Jie Sun, Qitao Tan, Wusong Yang, Bingxin Liu, Bin Xu*,, Adv. Synth. Catal. 2014, 356, 388-394.


      （最后更新日期：2024.10.31）

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